sumo
Gorelatide, inozivikanwawo se n-acetyl-serine - aspartic acid - proline - proline -(N-Acetyl-Ser-Asp-Ls-Pro), yakapfupikiswa seAc-SDKP, is an endogenous tetrapeptide, nitrogen end acetylation, yakaparadzirwa zvakanyanya zvakasiyana-siyana zvenyama uye mvura yemuviri mumuviri.Iyi tetrapeptide inoburitswa neprolyl oligopeptidase (POP), iyo inonyanya kukonzerwa neinotangira thymosin.Kuiswa muropa kunowanzova pachiyero che nanomole.
okinetics
Zvinoenderana neiyo pharmacokinetic yekudzidza yeGoreratide, mushure mejekiseni remutsinga, Gorelatide inokurumidza kushatisa nehafu yehupenyu hwe4 ~ 5min chete.Gorelatide inocheneswa kubva muplasma yevanhu nenzira mbiri:①Angiotensin-inoshandura enzyme (ACE) -inotungamirirwa nehydrolysis;②Glomerular filtration.Iyo hydrolysis yeangiotensin inoshandura enzyme (ACE) ndiyo nzira huru yegorelatide metabolism.
Biological chiitiko
Gorelatide imhando yeakawanda physiological regulatory factor ine akasiyana biological zviitiko.Yakambotaurwa kuti Gorelatide inogona kudzivirira kupinda kweiyo yekutanga hematopoietic stem masero muchikamu cheS uye kuita kuti ive yakamira muchikamu cheG0, ichivharira basa reiyo hematopoietic stem masero.Zvakazoonekwa kuti Gorelatide inogona kuvandudza epidermal replanting simba nekusimudzira kuumbwa kwetsinga yeropa uye kukurumidza kuporeswa kwemaronda mune yakakuvadzwa vascularized epidermal grafts.Gorelatide inogona kudzivisa kusiyana kwemasero emapfupa emapfupa anokurudzirwa neMGM kuva macrophages, nokudaro achitamba basa rinopesana nekuputika.Gorelatide ichangobva kuwanikwa inodzivisa kuwanda kwemasero akasiyana-siyana.
use
Se polypeptide organic nyaya, Gorelatide inogona kushandiswa semishonga mbishi zvinhu.
Nguva yekutumira: Kubvumbi-26-2023