Glucagon-like peptide 1 receptor (GLP-1R) agonist akawanikwa achideredza kushandiswa kwedoro mumakonzo uye vanhu vakafuta vane doro rekushandisa kusagadzikana (AUD).Nekudaro, yakaderera doses ye semaglutide (semaglutide), ine simba inhibitor yeGLP-1, yakaratidzwa kuderedza kushandiswa kwedoro mumakonzo uye vanhu vakafuta vane AUD.Mukana wekuti agonist ane simba rakawanda uye kuwirirana kweGLP-1R) anodzora mhinduro dzine chekuita nedoro mumakonzo, pamwe chete nemagadzirirwo etsinga, hazvizivikanwe.
Somallutide, mushonga unoshandiswa pakurapa chirwere cheshuga chechipiri uye kufutisa, unogona kunge uri mushonga unoshanda wekupindwa muropa nedoro.mune chidzidzo chakabudiswa mupepanhau repasi rose eBioMedicine rakanzi "Semaglutide Inoderedza Kunwa Doro uye Kudzokorora-kufanana Kunwa muMakonzo Evarume neVakadzi," Masayendisiti kubva kuYunivhesiti yeGothenburg nemamwe masangano akawana kuti somallutide inogona kuderedza kunwa doro uye kunwa doro mumakonzo. zvinopfuura hafu.
Kudiwa kwe somallutide, inotengeswa pasi pemazita emhando yakadai seOzempic (semaglutide), yakawedzera kubva apo mushonga wacho wakabvumirwa kurapwa kwekufutisa, iyo ichangobva kuita kuti zvive zvakaoma kuwana;Pavewo nenhaurwa dzevane chirwere cheshuga kana kuti vakafuta vachiti havi yedoro yakadzikira mushure mekunge vatanga kunwa mushonga uyu.Mazuva ano, vanhu vane doro vanobatwa nemusanganiswa wepfungwa dzepfungwa uye zvinodhaka.Parizvino kune mishonga mina yakabvumidzwa.Sezvo kudhakwa nedoro chirwere chine zvikonzero zvakawanda uye kushanda kwakasiyana-siyana kwemishonga iyi, kugadzirwa kwenzira dzakawanda dzokurapa kunonyanya kukosha.
Somallutide mushonga unoshanda kwenguva refu unongoda kutorwa kamwe chete pasvondo, uye ndiwo mushonga wekutanga kuita paGLP-1 receptor unogona kutorwa sepiritsi.Muchidzidzo ichi, vatsvakurudzi vakarapa makonzo anovimba nedoro nesomalutide, iyo yakaderedza zvakanyanya kunwa doro remakonzo uye yakatoderedza kunwa kwakabatana nekudzokazve, dambudziko guru kune vanhu vanodhakwa nedoro nokuti vanhu vanodzoka zvakare mushure menguva yekurega uye vanonwa doro rakawanda. kupfuura zvavaiita vasati vamborega.Makonzo akabatwa akakwanisa kuderedza kunwa kwavo doro nehafu kana zvichienzaniswa nemakonzo asina kurapwa, vaongorori vakati.Chinhu chinonakidza chakawanikwa muchidzidzo ndechekuti somallutide yakaderedza kunwa doro zvakaenzana mumakonzo echirume neechikadzi.
Chidzidzo chacho chakarondedzerawo chiitiko chakanaka chinoshamisa, kunyange zvazvo zvidzidzo zvekliniki zve somallutide zvichiri kure kure zvisati zvagona kushandiswa kurapa kudhakwa nedoro;Kuenderera mberi, mushonga uyu unogona kunyanya kubatsira kune vanhu vane uremu hwehuremu uye kudhakwa nedoro, uye vaongorori vanoti mhedzisiro yacho inogona kuendesa kuvanhu, sezvimwe zvidzidzo zvezvinodhaka zvekupikiswa nedoro vachishandisa mhando dzekutsvagisa dzinoratidza kuti vanhu vanogona kunge vaine maitiro ekurapa akafanana kana mhedzisiro. semakonzo.Purofesa Elisabet Jerlhag anotaura kuti, chokwadika, pane misiyano pakati pefundo dzinoitwa mumhuka navanhu, uye vaongorori vanofanira kugara vachirangarira misiyano iyi;Muchiitiko ichi, zvakadaro, ongororo yapfuura muvanhu yakaratidza kuti vhezheni yechinyakare yemushonga wechirwere cheshuga unoshanda paGLP-1 wakawanikwa uchideredza kunwa doro muvanhu vakafuta nedoro.
Chidzidzo chemazuva ano chakaongororawo kuti sei mushonga somallutide unoderedza kunwa doro rega rega, zvichiratidza kuti kuderedza doro-induced brain mibairo uye chirango chinogona kunge chiri chinhu chinokonzera;Mubepa, vaongorori vakawana kuti inokanganisa mubairo uye chirango chehuropi hwegonzo.Kunyanya zvakanyanya, inobata iyo nucleus accumbens nzvimbo, inova chikamu che limbic system.Vatsvakurudzi vanotenda kuti doro rinoita kuti mubairo wehuropi uye chirango chishande, zvichiita kuti dopamine isunungurwe, iyo inogona kuonekwa muvanhu nemhuka, uye izvi zvinovharwa mushure mokunge mbeva dzarapwa, izvo zvinogona kutungamirira kumubayiro wakaderera wedoro. kurangwa mumuviri, vaongorori vanotenda.
Mukupedzisa, zvigumisiro zvechidzidzo ichi zvinoratidza kuti somallutide inogona kuderedza kunwa doro, iyo inogona kupindirana nekuderedza doro-induced mubairo / chirango uye nzira ye nucleus accumbens."Sezvo somallutide yakaderedzawo huremu hwemuviri mumiviri yemakonzo ekunwa doro, zvidzidzo zvekiriniki zvenguva yemberi zvichaongorora kushanda kwesomallutide mukuderedza kunwa doro uye uremu hwemuviri muvarwere vakafuta vane dambudziko rekushandisa doro."
Nguva yekutumira: Nov-07-2023