Recombinant protein antigens inowanzova nema epitopes akati wandei, mamwe acho ari epitopes anotevedzana uye mamwe ari epitopes emuumbirwo.Mapolyclonal masoja ekudzivirira chirwere anowanikwa nekubaya mhuka nemaantigens ane denatured musanganiswa wemasoja ekudzivirira chirwere akanangana nemaepitopes ega ega uye anogona kushandiswa zvakazara kuona zvimiro zvechisikigo kana mapuroteni akatarwa.Rubatsiro rweparutivi rwekushandisa denatured mapuroteni sema immunogens nderekuti mapuroteni akacheneswa anowanzo kuve akawanda immunogenic uye anogona kukurudzira yakasimba immune immune mumhuka.
Matauriro eEscherichia coli anowanzo kusarudzirwa zvinangwa zveantigenic nekuti ndiyo inodhura zvakanyanya maererano nenguva nemari.Kuti uvandudze mukana weiyo inotarirwa mapuroteni kutaura uye nyore kwekucheneswa, dzimwe nguva chimedu chidiki cheprotein inotariswa, senge chaiyo domain, inoratidzwa.
Iyo mitatu-dimensional chimiro cheprotein
Iyo chaiyo Domain yeProtein
Kana chinangwa chekugadzirisa antibody chiri chekutsvaga wb chete, ndeyehupfumi uye inokurumidza kushandisa synthetic duku peptide se antigen, asi kune ngozi yekushaya simba kwekudzivirira muviri kana kusagadziriswa nekuda kwekusarudzwa kusina kukodzera kwepeptide segment.Sezvo kugadzirira kwemasoja ekudzivirira chirwere kunoda nguva yakareba, zvikamu zviviri kana zvitatu zvakasiyana zvepeptide zvinowanzosarudzwa kugadzirira masoja ekudzivirira chirwere achishandisa polypeptide antigen kuve nechokwadi chekubudirira kwekuedza.
Kuchena kwepolypeptide antigen yekudzivirira kunodiwa kuve kwakakura kupfuura 80%.Kunyangwe hutsanana hwepamusoro hunogona kuwana masoja ekudzivirira chirwere ane humbowo huri nani, mukuita, mhuka dzinogara dzichiburitsa huwandu hukuru hweasiri chaiwo masoja ekudzivirira chirwere, nekudaro maskiti mabhenefiti eantigen kuchena.
Pamusoro pezvo, kugadzirira kwemasoja ekudzivirira chirwere kubva kudiki peptides kunofanirwa kuve kwakabatana kune yakakodzera inotakura antigen kuti iwedzere kusasimba kwayo.Maviri akajairika antigenic vatakuri ndeye KLH uye BSA.
Nguva yekutumira: Mar-23-2023