Aya antimicrobial peptides pakutanga akatorwa kubva kune dziviriro masisitimu ezvipembenene, zvinoyamwisa, amphibians, nezvimwewo, uye anonyanya kusanganisira mana mapoka:
1. cecropin pakutanga yaivepo mu immune lymph yeCecropiamoth, iyo inonyanya kuwanikwa mune zvimwe zvipembenene, uye yakafanana bactericidal peptides inowanikwawo mumatumbo enguruve.Iwo anowanzo ratidzwa neakasimba alkaline N-terminal nzvimbo inoteverwa nerefu hydrophobic fragment.
2. Xenopus antimicrobial peptides (magainin) inotorwa kubva mumhasuru uye dumbu rematatya.Chimiro che xenopus antimicrobial peptides chakawanikwawo kuva helical, kunyanya munzvimbo dze hydrophobic.Kugadziriswa kwe xenopus antipeptides mu lipid layers yakadzidzwa neN-yakanyorwa yakasimba-chikamu NMR.Zvichienderana nekuchinja kwekemikari yeacylamine resonance, helice dze xenopus antipeptides dzaive dzakafanana bilayer nzvimbo, uye dzaigona kuchinjika kuita 13mm keji ine periodic helical chimiro che30mm.
3. Defensin Defense peptides inotorwa kubva kuvanhu polykaryotic neutrophil rabbit polymacrophages ine yakazara nuclear lobule uye masero ematumbo emhuka.Boka remaantimicrobial peptides akafanana nemammalian defense peptides akatorwa kubva kune zvipembenene, zvinonzi "insect defense peptides".Kusiyana nemammalian kudzivirira peptides, zvipembenene zvekudzivirira peptides zvinongoshanda kurwisa mabhakitiriya eGram-positive.Kunyangwe zvipembenene zvekudzivirira peptides zvine matanhatu maCys asara, asi nzira ye disulfide bonding kune mumwe nemumwe yakasiyana.Iyo intramolecular disulfide bhiriji inosunga maitiro eantibacterial peptides yakatorwa kubva kuDrosophila melanogast yakanga yakafanana neiyo yezvidyarwa zvekudzivirira peptides.Pasi pemamiriro ekristaro, peptides yekudzivirira inoratidzwa se dimers.
4.Tachyplesin inotorwa kubva kuhoveshoe crabs, inonzi horseshoecrab.Zvidzidzo zvekugadzirisa zvinoratidza kuti inotora antiparallel B-kupeta gadziriro (3-8 nzvimbo, 11-16 nzvimbo), umoβ-angle yakabatana kune mumwe nemumwe (8-11 nzvimbo), uye maviri disulfide zvisungo zvinogadzirwa pakati pe7 uye 12 nzvimbo, uye pakati pe3 uye 16 nzvimbo.Muchimiro ichi, iyo hydrophobic amino acid iri kune rumwe rutivi rwendege, uye matanhatu cationic masara anoonekwa pamuswe wemorekuru, saka chimiro zvakare chiri biophilic.
Izvi zvinotevera kuti inenge yese antimicrobial peptides ndeye cationic muzvisikwa, kunyange zvazvo zvakasiyana pakureba uye urefu;Pamusoro pekupedzisira, ingave iri muchimiro che alpha-helical kanaβ-kupeta, bitropic chimiro ndicho chinhu chakajairika.
Nguva yekutumira: Kubvumbi-20-2023