Nezvedu:
Peptide iketani yeamino acids yakabatanidzwa ne peptide bond.Peptides inonyanya kubatanidzwa mukugadzirisa mapuroteni, angiogenesis, kuwedzera kwesero, melanogenesis, kutama kwesero, uye kuzvimba.Bioactive peptides yakashandiswa zvakanyanya muindasitiri yezvizorwa mumakumi emakore apfuura.Peptides inoda yakaderera molecular uremu (> 500 Da), kuitira kuderedza kupararira kwepeptide pakati peepidermal layers, kugadzikana kwepamusoro uye kunyungudika.Kwemakore, nharaunda yesainzi yakagadzira diki uye yakagadzikana peptide chimedu chinomisikidza kugadzirwa kwe collagen uye kuderedza kuunyana kumeso uye pigmentation.Trifluoroacetyl tripeptide-2 (sequence: TFA-Val-Try-Val-OH) tripeptide synthesis, yakagadzirwa sematrix metalloproteinase uye elastase inhibitor.In vitro zvidzidzo pamusoro pekuchengetedzwa kweECM ne trifluoro-acetyl tripeptide 2(TT2), iyo synthesis yeproteoglycan mu cell-matrix kupindirana, uye mhedzisiro yeprogerin synthesis muvanhu vakakura fibroblasts yakaonekwa munguva pfupi yapfuura se co-inducer yemaserura. senescence.Mhedzisiro yacho inoratidza kuti trifluoroacetyl tripeptide 2 ine huwandu hwakakura hwezvinhu zvinorwisa kuchembera.Izvi zvinoderedza progerin synthesis, inowedzera kugadzirwa kweproteoglycan, uye inoderedza collagen, nokudaro kuderedza makwinya nekuvandudza kuoma kwetishu.Uye zvakare, iyo anti-wrinkling, anti-kuyerera yakarembera uye ganda kusimbisa mhedzisiro yakaongororwa mune maviri in vitro split face zvidzidzo.Trifluoroacetyl tripeptide 2 yakaratidzwa kuve neinofambira mberi mhedzisiro pamakwinya, kusimba, elasticity, uye sagging.
Trifluoroacetyl tripeptide-2 inogona kunonoka kuchembera here?
Zvidzidzo zvakaratidza kuti cell senescence ine hukama hwepedyo neProgerin.Nekuchembera, presenilin inounganidza zvakanyanya uye zvakanyanya mumuviri, zvichitungamira kune hurema hwenyukireya uye kukuvara kweDNA, zvichitungamira kune huwandu hwekuchembera kweganda.Trifluoroacetyl tripeptide-2 is an active tripeptide of Elafin, a derivative of elastase inhibitor.Inoderedza Progerin synthesis uye inovandudza ganda laxity, sagging uye wrinkles.
Mechanism
1. Inhibit the synthesis yeProgerin kunonoka senescence yemasero.
2. Kurudzira kugadzirwa kwesyndecan uye kurebesa hupenyu hwesero.
3. Inhibisa basa rematrix metalloproteinases MMP1, MMP3 uye MMP9, kuderedza kuparara kwemaprotein e-extracellular matrix uye kuchengetedza kuvimbika kwavo.
4. Inhibit elastase basa, kuderedza kupera kwe elastin, uye kuita kuti ganda rive rakasimba uye rinowedzera.
Application
Inokodzera marudzi ose e-anti-wrinkle uye anti-kuchembera, kusimbisa kugadzirisa, anti-photoaging, post-natal uye post-sun body care, etc. Inowedzerwa muchikamu chekupedzisira chekugadzirwa kwezvizoro.
Nguva yekutumira: May-22-2023