Ko iyo antimicrobial peptide Omiganan inogonawo kuwana antibacterial mhedzisiro

Chirungu: Omiganan

Chirungu: Omiganan

Nhamba yeCAS: 204248-78-2

Molecular formula: C₉₀H₁₂₇N₂₇O₁₂

Molecular uremu: 1779.15

Kutevedzana: ILRWPWWPWRRK-NH2

Kuonekwa: chena kana isina-white powder powder

 

Maitiro Omiganan anoita:

Iyo idiki peptide uye saka yakaoma kuziva uye kuisa chiratidzo cheproteolysis;Iyo inomisikidzwa paC terminus kuti iwedzere kuramba proteolysis uye kubvisa mhosva yakaipa yeboka recarboxyl.Iyo inonzi amphiphilic uye inogona kupindirana zvakasimba ne cell membrane.Sero membrane inotarisirwa kuve imwe yezvavanotarisira zvikuru.Ipolycation inofarira kusangana kwavo nehutachiona husina kunaka membranes uye zomeric yekunze yelipopolysaccharide (LPS) ine mammalian membranes pane peptidoglycan.Mubhakitiriya, iyo membrane inogoneka zvakare yakaipa kupfuura mumasero emammalian, ayo anogona kuwedzera kusungirirwa kwemishonga inorwisa mabhakitiriya uye kufambisa.Chinhu chekupedzisira chikanganiso chekiriniki iyo antiinflammatory cytidine inewo basa pane erythrocytes, nepo Omiganan ichiita seine hemolytic shoma.Sezvambotaurwa pamusoro apa, zvakasara zvakasara zve omiga-nan zviri pedyo nechiteshi chimwe nechimwe, kure nepakati pe hydrophobic nzvimbo ye peptide, uye iyo yose yakanaka yepeptide inowedzera kubva ku4+ kusvika ku5+, iyo inogona kutsanangurwa nekuderedza hemolysis. , sezvo shanduko idzi dzisingakodzeri zvinhu zvakaita sepeptide zvine chekuita nezwitt-rionic mammalian membranes.Izvi zvinotsigirwa nemigumisiro yeStaubitz nevamwe, apo chidimbu chepakati chekuchengetedza antiinflammatory cetin mu omiganan chinosanganiswa nebasa, asi chidimbu chekupedzisira chinoratidzika sechigadzirisa chinangwa chechinangwa.

Omiganan inoshandiswa kune:

Omiganan ibhuku rekugadzira cationic antimicrobial peptide parizvino iri kuvandudzwa yekudzivirira hutachiona hune chekuita necatheter uye nekurapa mburwa uye rosacea.Muchidzidzo chino, takaongorora kushanda kwepamusoro pekushandisa kweomiganan gel mumamodeli maviri ekudyara ganda (mu vivo porcine ganda uye in vivo guinea pig skin).omiganan0 yakaedzwa mune ex vivo porcine ganda colonization modhi 1 kusvika 2% yegel agent yakaratidza yakasimba dosi-inotsamira mhedzisiro inopesana neGram-positive uye Gram-negative mabhakitiriya uye mbiriso, ine yakanyanya mhedzisiro inoonekwa pakati pe1 ne2%.Pakanga pasina mutsauko wakakosha mukuita pakati pemethicillin-resistant uye susceptible Staphylococcus aureus, uye basa rezvinodhaka harina kukanganiswa nehukuru hwechinhu chakavharwa.Omiganan1% gel yakange ine kukurumidza antimicrobial chiitiko, ine 2.7log (10) kuderedzwa kwekoloni-forming units yeStaphylococcus epidermolis/saiti pa1 h uye 5.2log (10) kuderedzwa mu flagella/saiti pa24 h mushure mekushandisa.Iyo yakasimba antibacterial uye antifungal chiitiko cheOmiganan1% gel yakasimbiswa nezvimwe zvidzidzo mune yedolphin ganda colonization modhi.Mukupfupisa, maOmiganem gels akave akaratidzwa kuti ane kukurumidza bactericidal uye bactericidal mhedzisiro ine yakajeka-inotsamira dhigirii pane yakafara spectrum yezvipenyu zvinotapukira.Iyi mhedzisiro inowedzera kuratidza kugona kwemushonga senge topical antimicrobial agent.


Nguva yekutumira: Jun-27-2023