Masero-anopinda peptides madiki peptides anogona kupinda nyore musero membrane.Iri kirasi yemamorekuru, kunyanya maCPP ane mabasa ekunangisa, ane vimbiso yekuendesa zvinodhaka kunoshanda kumaseru anonangwa.
Naizvozvo, tsvakiridzo pazviri ine zvimwe biomedical kukosha.Muchidzidzo ichi, maCPP ane mabasa akasiyana-siyana e-transmembrane akadzidzwa pamwero wekutevedzana, achiedza kutsvaga zvikonzero zvinokanganisa basa re transmembrane reCPPs, kusiyana kwekutevedzana pakati peCPP nemabasa akasiyana uye NonCPPs, uye kuunza nzira yekuongorora maitiro ehupenyu.
CPPs uye NonCPPs sequences dzakatorwa kubva kuCPPsite dhatabhesi uye akasiyana mabhuku, uye transmembrane peptides (HCPPs, MCPPs, LCPPs) ine yakakwirira, yepakati, uye yakaderera transmembrane chiitiko yakatorwa kubva kuCPPs sequences kuvaka data seti.Kubva pane idzi data seti, zvidzidzo zvinotevera zvakaitwa:
1, Iyo amino acid uye yechipiri chimiro kuumbwa kweakasiyana anoshanda CPPs uye NonCPPs akaongororwa neANOVA.Zvakaonekwa kuti electrostatic uye hydrophobic interactions yeamino acids yakaita basa rinokosha mukushanda kwetransmembrane yeCPPs, uye chimiro chehelical uye kusungirirwa kusina kuitika kwakakanganisawo basa re transmembrane reCPPs.
2. Zvinhu zvepanyama uye zvemakemikari uye kureba kweCPPs nemabasa akasiyana-siyana zvakaratidzwa pane maviri-dimensional ndege.Zvakaonekwa kuti maCPP neNonCPP ane mabasa akasiyana-siyana anogona kubatanidzwa pasi pezvimwe zvinhu zvakakosha, uye HCPPs, MCPPs, LCPPs uye NonCPPs zvakakamurwa kuva mapoka matatu, zvichiratidza kusiyana kwavo;
3. Mubepa rino, pfungwa yemuviri nekemikari centroid yekutevedzana kwebhayoloji inosumwa, uye zvisaririra zvinoumba kutevedzana zvinoonekwa sezvimedu zvemapoinzi, uye kutevedzana kunobviswa sechikamu chehurongwa hwekutsvaga.Iyi nzira yakashandiswa pakuongorora kweCPPs nekufungidzira maCPP ane mabasa akasiyana-siyana mundege ye3D nePCA nzira, uye zvakaonekwa kuti maCPP akawanda akabatanidzwa pamwe chete uye mamwe maLCPP akabatanidzwa pamwe chete neNonCPPs.
Ichi chidzidzo chine zvarinoreva pakugadzirwa kweCPPs uye kunzwisisa kusiyana kwekutevedzana kweCPPs nemabasa akasiyana.Pamusoro pezvo, nzira yekuongorora yemuviri nekemikari centroid yekutevedzana kwebiological yakaunzwa mubepa rino inogona zvakare kushandiswa kuongorora mamwe matambudziko ebhayoloji.Panguva imwecheteyo, anogona kushandiswa seyekuisa paramita kune mamwe matambudziko emhando yebiological uye kuita basa mukuzivikanwa kwepateni.
Nguva yekutumira: Jun-15-2023