Tecosactideinogadzirwa 24-peptide corticotropin analogue.Iyo amino acid sequence yakafanana ne24 amino acids yeamino-terminal yenatural corticotropin (munhu, bovine uye porcine), uye ine yakafanana physiological chiitiko seyakasikwa ACTH."Iyo inoratidzwa nekusavapo kwema antibody reactions, kazhinji isina mhedzisiro yakakomba, uye inonyanya kukodzera kuvarwere vane allergic reaction kana vasingashande kune chaiyo porcine corticotropin."
"Inokonzera adrenal hyperplasia, inokurudzira kubudiswa kwemahomoni e-adrenocortical, kunyanya (cortisol) uye mamwe mineralocorticoids akadai secorticosterone, uye inomutsawo kugadzirwa kwe androgens, asi nemigumisiro isina simba."
Iri bepa rinotsanangura muchidimbu iyo ticcotide nemhedzisiro yayo yemishonga
Ikoko kwakanga kune zvishoma zvinokonzerwa nealdosterone secretion.Hafu yehupenyu maawa matatu.Muna 2008, iyo FDA yakabvumidza Tecokotide kubva kuNovartis kuti iongororwe adrenal insufficiency.Parizvino iri kudzidzwa kuRandboudUniversity yekurapa idiopathic membranous nephropathy.
Iyo yese yemvura chikamu synthesis nzira ndiyo yekubatanidza nzira yeticacotide.Iyi nzira ine nhanho dzakawanda, nguva refu yekubatanidza, uye inoda zvinodhura zvinokonzeresa uye yakakwirira-kudzvanywa midziyo, iyo ine zvakaipira kudhura kwakanyanya, tsvina yakawanda, njodzi yekushanda, uye goho rakaderera.Izvo zvave zvichishumwa kuti synthesis imwe neimwe uchishandisa Z-protection strategy, umo hydrogenation inoshandiswa kubvisa chigadziko chekudzivirira pane imwe neimwe nhanho, ine matanho akareba, kushanda kwakaoma, mari yakakwirira uye goho rakaderera.Serine inowanzoita racemization nekuda kwekubatana-kune-imwe panguva yekucheneswa, izvo zvakaoma kuchenesa.
"Kufanana nehomoni yeadrenocorticotropic, ticcotide inokurudzira kubudiswa kwemahomoni ecortical (kunyanya cortisol) kubva muadrenal cortex."Naizvozvo, pakanga pasina mhedzisiro muvarwere vane yakanyanya adrenocortical dysfunction.
Ticocotide is synthetic polypeptide ine makumi maviri nemana amino acids.Izvo zvakafanana mukugadzirisa kune yekutanga kusvika ku24th amino acids yeACTH.Intravenous administration inokurumidza kuwedzera cortisol yeropa.Kudonhedza kweropa kunopfuurira kunofanirwa kushandiswa kuchengetedza cortisol yeropa.Nejekiseni re intramuscular, serum cortisol yakasvika pakakwirira pa1h mushure mejekiseni.Mushure meizvozvo, yakakwira cortisol inogona kuchengetedzwa kweanenge maawa makumi maviri nemana.
Nguva yekutumira: Jul-11-2023