PYY peptides ndeye antifungal uye inochengetedza intestinal microbial hutano

Boka parakaona chimiro ichi cheC. albicans vachishandisa PYY, data yakaratidza kuti PYY yakamisa kukura kwemabhakitiriya aya, ichiuraya mamwe fungal marudzi eC. albicans uye kuchengetedza symbiotic yeast yeC. albicans.

Boka raEugene Chang paYunivhesiti yeChicago rakaburitsa bepa mujenari Sainzi rakanzi: Peptide YY: A Paneth cell antimicrobial peptide inochengetedza Candida gut commensalism.

YY peptide (PYY) Ihomoni yemudumbu inoratidzwa uye yakavanzwa nemasero eenteroendocrine (ECC) kudzora havi nekugadzira satiety.Zvidzidzo zvenguva pfupi yapfuura zvakaona kuti mudumbu usiri-chaiyo PanethCell zvakare inoratidza chimiro chePYY, chinogona kuita seantimicrobial peptide (AMP), iyo inoitawo basa rakakosha kuchengetedza intestinal microbiota ine hutano uye kudzivirira Candida albicans kubva pakuva njodzi pathogenic. mode.

Zvishoma zvinozivikanwa nezve kudzorwa kweaya mabhakitiriya negut microbiome yedu.Tinongoziva kuti mabhakitiriya ari kunze uko, asi hatizivi kuti chii chinoita kuti ave akanaka kune hutano hwedu.Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti YY peptides inonyanya kukosha kuchengetedza intestinal bacterial symbiosis.

Pakutanga, timu yanga isati yagadzirira kudzidza mabhakitiriya mugut microbiome.Apo Joseph Pierre, munyori wekutanga webepa, akanga achidzidza masero emudumbu eEndocrine ePYY anogadzira mbeva, Dr. Joseph Pierre akaona kuti PYY inewo Panethcells, iyo inokosha kudzivirira kwekudzivirira mudumbu remammalian uye kudzivirira kuwanda kwebhakitiriya ine ngozi. kuburikidza nemetabolizing akati wandei bacterosuppressive compounds.Izvi hazviratidzike zvine musoro nekuti PYY yaimbofungidzirwa kuti ihomoni yekuda kudya.Chikwata pachakawona akasiyana mabhakitiriya, PYY yakawanikwa yakashata pakuauraya.

PYY peptides ndeye antifungal uye inochengetedza intestinal microbial hutano

Nekudaro, pavakatsvaga mamwe marudzi emapeptide akafanana, vakawana PYY-yakafanana peptide -Magainin2, antimicrobial peptide iripo paganda reXenopus inodzivirira kubva kuhutachiona uye fungal.Naizvozvo, timu yakatanga kuyedza antifungal zvimiro zvePYY.Muchokwadi, PYY haingori inoshanda zvakanyanya antifungal mumiriri asiwo yakanyatso fungira mumiriri.

Yakakwana, isina kuchinjwa PYY ine makumi matatu nematanhatu amino acids (PYY1-36) uye ine simba antifungal peptide apo maPaneth masero anoaisa muura.Asi kana endocrine masero agadzira PYY, inobviswa maviri amino acids (PYY3-36) uye inoshandurwa kuita intestinal hormone inokwanisa kufamba nemuropa kugadzira pfungwa yekuzara inoudza uropi kuti hauna nzara.

Candida albicans (C.albicans), inozivikanwawo seCandida albicans, ibhakitiriya rinowanzomera mumuromo, paganda nemuura.Iyo inokodzera mumuviri mune yekutanga mbiriso chimiro, asi pasi pemamiriro epakati inotendeuka kuita inonzi fungal chimiro, iyo inobvumira kuti ikure muhuwandu, ichitungamira kune thrups, muromo nehuro hutachiona, hutachiona hwemukadzi, kana zvakanyanya kuoma. systemic zvirwere.

Boka parakaona chimiro ichi cheC. albicans vachishandisa PYY, data yakaratidza kuti PYY yakamisa kukura kwemabhakitiriya aya, ichiuraya mamwe fungal marudzi eC. albicans uye kuchengetedza symbiotic yeast yeC. albicans.