Kuongorora uye kushandiswa kwecerulein

Overview

Caerulein, inozivikanwawo se cerulein, iganda redatya reAustralia HYlacaerulea rine gumi amino acids.Iyo decapeptide molecule inopiwa ne trifluoroacetate iyo inoshanda secholecystokinin analogue pane pancreatic vesicular masero uye inogona kutungamirira kukuvanda kwenhamba yakawanda yekudya enzymes uye pancreatic juice, zvichiita kuti acute edematous pancreatitis.Cerutin inogona kushandiswa kudzidza Nf-κb up-regulation mapuroteni akadai se intercellular adhesion molecule-1 (ICAM-1) zvinhu zvine chokuita nekuputika zvakadai seNADPH oxidase uye Janus kinase mediated signal transduction.Yakashandiswa zvinobudirira kumisikidza mhando dzeacute pancreatitis mumakonzo, mbeva, imbwa, uye maSyria hamsters (AP).Zvinwiwa zvinoiswa mutsinga zvinonwiwa zvakanyanya nejekiseni remutsinga, redermal, kana kuti intraperitoneal.Inoshandiswa zvakanyanya mumakiriniki ekuedzwa kweacute edematous pancreatitis, uye in vitro kuyedza inoshandiswa kune esero mhando.Mukuwedzera, inoshandiswa pakuongorora basa re gallbladder.

Kuongorora uye kushandiswa kwecerulein

Ruzivo rwakadzama

Kuonekwa: chena poda

Nhamba yeCAS: 17650-98-5

Gutuo Nhamba : GT-F055

Sequence: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Molecular formula: C58H73N13O21S2

Molecular uremu: 1352.4

Solubility: Yakanyungudutswa mu 50mM ammonium hydroxide pamusangano we 1.0mg/ml

Application

1. Inoshandiswa zvakanyanya mukuenzanisira kweacute edematous pancreatitis mumakiriniki ekuedzwa.

2. Kushandisa kune masero emhando mu vitro.

3. Inoshandiswa pakuongorora kushanda kwe gallbladder.

Kugadzira modhi yekudzidza kweacute pancreatitis yekudzidza kwecerulein (AP) cell biology, pathophysiological maitiro uye kuratidzwa kwezvirwere zveorganic mune acute pancreatitis.Pamusoro pekuongorora shanduko yemapulmonary yeAP chirwere, inogona zvakare kuratidza zvinobudirira iyo visceral endocrine kusangana senge nhanho yemetabolin neCCK.Inogona zvakare kushandiswa kuongorora kudzoreredzwa uye kudzoreredzwa kwematishu akakuvadzwa mushure mekugumiswa kwezvinhu zvine njodzi.

5. Kushandiswa kweCaerulein cerulein (cerulein) uye LPS kugadza pancreatitis mienzaniso inogona kubudisa synergistic madhara, yekare inogona kukurudzira pancreatic enzymes kuti iparadze pancreas, uye inoramba ichiita masero ekuputika kuti asunungure zvinhu zvinopisa.Zvadaro, LPS inovhiringidza mhinduro yakajairika yevarevereri vanopisa, nekudaro kugadzira pancreatitis yenzvimbo sechirongwa chakakomba chekuzvimba chiitiko.

6. Cerulein inogona kushandiswa kudzivirira gallbladder kurwadziwa, renal colic, uye intermittent claudication kurwadziwa.Inowanzo onekwa seanopokana kephalin anopikisa.