Action mechanism
Enzymes mapuroteni anokonzeresa kuita kwemakemikari.Iyo enzyme inodyidzana neiyo substrate kuishandura kuita chigadzirwa chekupedzisira.Inhibitors inosunga kune mumwe nemumwe kudzivirira iyo substrate kupinda munzvimbo inoshanda ye enzyme uye / kana kudzivirira iyo enzyme kubva pakukonzeresa maitiro.Kune marudzi akawanda ezvipingamupinyi anosanganisira: asiri chaiwo, asingadzoreki, anodzoreka - anokwikwidza uye asina kukwikwidza.Reversible inhibitors inosunga kune ma enzymes ane non-covalent interactions (semuenzaniso, hydrophobic interactions, hydrogen uye ionic bonds).Nonspecific kudzora matanho anosanganisira pakupedzisira denaturing chikamu cheprotein ye enzyme uye nekudaro kudzivirira zvese zvemuviri kana kemikari kuita.Specific inhibitors inoshanda pane imwe enzyme.Mazhinji chepfu anoita zvinoenderana neakananga ma enzymes.Competitive inhibitors ese makomisheni anonyatso kufanana nekemikari chimiro uye molecular geometry ye reaction substrate.Iyo inhibitor inogona kupindirana neiyo enzyme panzvimbo inoshanda, asi hapana mhinduro inoitika.Noncompetitive inhibitors zvinhu zvinodyidzana nema enzymes asi kazhinji hazvidyidzane panzvimbo inoshanda.Chinangwa chemumbure weasina kukwikwidza inhibitor ndechekushandura chimiro che enzyme, nekudaro ichikanganisa nzvimbo inoshanda, kuitira kuti substrate isakwanise kupindirana neiyo enzyme kuita.Non-competitive inhibitors anowanzo shandurwa.Irreversible inhibitors inoumba yakasimba covalent zvisungo nema enzymes.Mamwe eaya inhibitors anogona kuita pane kana kutenderedza saiti inoshanda.
use
Ma Enzymes anoshandiswa zvakanyanya mukutengeserana muminda yemaindasitiri, senge yekusuka ndiro, chikafu uye maindasitiri ekubikisa doro.Maprotease anoshandiswa mu “microbial” washing powders kuti akurumidze kuparara kweprotein mutsvina yakaita seropa nemazai.Iko kushandiswa kwekutengeserana kwema enzymes kunosanganisira kuti anonyungudika mumvura, izvo zvinoita kuti zviome kudzokorodza, uye kuti zvimwe zvigadzirwa zvekupedzisira zvinotadzisa enzyme basa (feedback control).
Mamorekuru emishonga, mamorekuru mazhinji emishonga anonyanya kuita enzyme inhibitors, uye madhiragi enzyme inhibitors anowanzo kuratidzwa nehunhu uye mashandiro awo.Hunhu hwepamusoro uye hunhu hwairatidza kuti mishonga iyi yaive nemaitiro akaderera uye huturu hwakaderera.Enzyme inhibitors inowanikwa mune zvakasikwa uye inorongwa uye inogadzirwa sechikamu chidiki che pharmacology uye biochemistry 6.
Chepfu dzechisikigo kazhinji ma enzyme inhibitors akashanduka kudzivirira miti kana mhuka dzakasiyana kubva kune zvikara.Uhu hwehupfu hwepanyama hunosanganisira akawanda emakemikari ane muchetura akambowanikwa.
Nguva yekutumira: Kubvumbi-25-2023