Integrin, kana integrin, inonzi heterodimer transmembrane glycoprotein receptor iyo inopindirana nemhuka sero adhesion uye kuisa chiratidzo.Inoumbwa neα uyeβ subunits.Inobatanidzwa mukugadzirisa kwezviito zvakasiyana-siyana zvemaserura zvinosanganisira kutama kwesero, kupinza masero, sero uye intercellular signing, cell adhesion, uye angiogenesis maitiro.Integrinαvβ3 ikozvino yakaongororwa zvakanyanya.Kuonekwa kwe integrinαvβ3 yakabatana zvakanyanya nekutama kwebundu, angiogenesis, kuzvimba uye osteoporosis.Integrin inoratidzwa zvakanyanya mune ese tumor tissues uye endothelial cell membranes ye neovascularization.Kuonekwa kwe integrin kwakabatana zvakanyanya nekutama kwebundu uye angiogenesis.Mumakore achangopfuura, zvidzidzo zvesainzi zvakaratidza kuti kune gumi nerimwe integrins anogona kusunga zvakananga kuRGD peptide, ari antagonistic peptides for integrin receptors.
RGD peptide inoiswa mumutsara RGD peptide uye RGD cyclic peptide.Kuenzaniswa nemutsara RGD peptide, RGD cyclic peptide ine yakasimba receptor kugarisana uye chaiyo yekugamuchira.Aya anotevera ndiwo akajairika marudzi uye nzira dzekubatanidza dzeRGD cyclic peptide.
Mhando dzakajairika dzeRGD cyclic peptides:
1. Cyclic peptides ine RGD sequences inoumbwa ne disulfide bonds
2. Cyclic peptides ine RGD sequences inoumbwa neamide bonds
Synthesis yeRGD cyclic peptide:
Iyo yekushandisa modhi ine chekuita neRGD cyclic peptide synthesis process mumunda weiyo yakasimba chikamu polypeptide synthesis tekinoroji.Nzira itsva ndeyekusarudza 2-chloro-triphenylmethyl chloride resin semutakuri wezvinodiwa, tanga wabatanidza yekutanga side chain carboxyl boka neboka rakakosha rekudzivirira reD aspartic acid amino acid, wozobatanidza iyo linear peptide yeRGD sequence peptide kune resin. , uye yekupedzisira amino acid kubvisa boka rekudzivirira FMOC pasina piperidine.Iyo yakatsanangurwa catalyst yakawedzerwa kuti ibvise side chain carboxyl kudzivirira boka rekutanga D aspartic acid zvakananga kubva kune resin, inoteverwa nekuwedzera kwepiperidine kubvisa amino kudzivirira boka FMOC yekupedzisira amino acid, inoteverwa nekuwedzerwa kweanosunga agent. kudzikisa mvura uye kuomesa boka recarboxyl neboka reamino rakafumurwa kubva kumusoro uye kumagumo kwemutsara peptide yakananga kubva kune resin muchimiro cheamide bond kuburitsa cyclic peptide.Pakupedzisira, iyo cyclic peptide inochekwa zvakananga kubva kune resin nemhinduro yekucheka.
Nguva yekutumira: Kubvumbi-24-2023