L-carnosine imorekuru diki rine yakasikwa dipeptide L-yakaita chimiro chinowanikwa muzvisikwa uye inoumbwa nemasikirwo edipeptide L-akaumbwa zvimiro anowanzo kuwanikwa muzvisikwa.Dipeptide inoumbwa ne β-alanine uye L-histidine.Carnosine ine zvakasiyana-siyana zvema cellular antioxidant, anti-aging uye physiological health care mabasa nemigumisiro yezvokurapa, zvakadai se hypertension, chirwere chemwoyo, senile cataract, ulcer recovery, anti-tumor, immune model test, anti-stress factors nezvimwe zvakadaro.
Basa re
Carnosine icarnosine yakawanikwa nemusayendisiti wekuRussia Gulevich pamwe chete necarnitine.MuUnited Kingdom, Korea, Russia, nedzimwe China, zvidzidzo zvakaratidza kuti carnosine ine simba rekudzivirira antioxidant uye inobatsira kuvanhu.Carnosine yakaratidzwa kuti inobvisa reactive oxygen species (ROS) inoumbwa nekunyanyisa oxidation yemafuta acids mu cell membrane panguva ye oxidative stress, pamwe ne α-β unsaturated aldehydes.
Zvidzidzo zvakawanda zvakaona kuti N-acetylcarnosine ine simba rakanaka mukudzivirira uye kurapwa kwecataract.Chimwe chezvidzidzo izvi chakaratidza kuti carnosine yakagadziridza cataracts inokonzerwa nekristalline opacities mumakonzo anokonzerwa nekutsvaga guanidine.Kunyange zvazvo zvirevo izvi zvichitsigira huwandu hwefungidziro kune ziso senge carnotin kurapwa kwecataract, ivo, kusvika parizvino, havana kutsigirwa zvizere neruzhinji rwezvekurapa munharaunda.The Royal Orthopedics, semuenzaniso, yakanga yataura kuti carnosine yakanga isina kuchengetedzeka kana kuti inoshanda mukurapa kwemusoro kwecataract.
Maererano nemushumo wa2002, carnosine inogona kuvandudza hukama hwevanhu uye kuwedzera mazwi anoshandiswa nevana vane autism, asi kuvandudzwa kunonzi muchidzidzo kunogona kubva mukuvandudzwa, placebo, kana zvimwe zvisina kunyorwa muongororo iyi.
Nzira yekugadzira
Parizvino, nzira dzekugadzira carnosine dzine zvimwe zvinokanganisa zvinowanzoitika: nekuda kwekuganhurwa kwekuita kweparutivi, iyi side reaction inoitwa nekubatanidzwa kweL-histidine imidazole ring.L-histidine ichatenderera zvishoma ne0.8% mukuita maitiro, kuderedza chibereko chechigadzirwa;Panguva imwecheteyo, zvakaoma kuparadzanisa L-carnosine neine yakanaka yakachena optical kuchena kubva kune zvinokuvadza zvinosanganiswa (yayo kutenderera maitiro, imidazole isomers, nezvimwewo), inokanganisa kuchena kwekutengeserana, nokuti iyi misanganiswa ine yakafanana physicochemical properties kune L-carnosine.Nekuda kwekuvapo kwemusanganiswa uyu, mhedzisiro yeL-carnosine ine chepfu, pane yepakutanga yakachena gadziriro.
Nzira itsva yekugadzirwa kweL-carnosine ndeyotevera: phthalic anhydride inobata β-alanine ne phthalic anhydride β-phthaloylalanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine kune phthaloyl-alanine β-alanyl chloride;L-trialkylsilane protective compound inobata ne trialkylchlorosilane kana hexahydroxysilane, inopindirana ne phthalyl β-alanyl chloride condensation ye hydrochloride, inobvisa boka rekudzivirira neine anhydrous alcohol, uye synthetates hydrochloride mu alkaline solution kuti iwane intermediate hydrochlorazites hydrochlorazites, hydrochlorazites hydrochlorazite uye intermediate hydrochlorazites hydrochloride. L-carnosine mune anhydrous doro.Ichi chigadzirwa chinonzi imidazole mhete paL-protected histidine kudzivirira mhedzisiro yeimidazole mhete paL-histidine nezvimwe zvinhu, uye kuwana yakachena L-carnosine ine yakaderera mhedzisiro uye yakakwirira yakazara goho uye zvirimo.
Nguva yekutumira: Oct-24-2023