Mupepa iri, maviri akakosha amino acids, glycine (Gly) uye alanine (Ala), anounzwa.Izvi zvinodaro nekuti vanogona kuita se base amino acids uye kuwedzera mapoka kwavari kunogona kugadzira mamwe marudzi emaamino acid.
Glycine ine kunakidza kunotapira, saka zita rayo rechiRungu rinobva kuGreek glykys (inotapira).Shanduro yeChinese yeglycine haina kungova nechirevo che "tapira", asiwo ine mataurirwo akafanana, ayo anogona kunzi muenzaniso we "kutendeka, kubudirira uye kunaka".Nekuda kwekunaka kwayo kunotapira, glycine inowanzoshandiswa sechinhu chinonhuwira muindasitiri yezvekudya kubvisa kuvava uye kuwedzera kutapira.Cheni yeparutivi yeglycine idiki ine atomu yehydrogen imwe chete.Izvozvo zvinomuita akasiyana.Iyo yakakosha amino acid isina chirality.
Glycine mumapuroteni inoratidzwa nehukuru hwayo hudiki uye kushanduka.Semuenzaniso, iyo mitsara mitatu helix conformation ye collagen yakakosha zvikuru.Panofanira kunge kune imwe glycine kune maviri ega asara, zvikasadaro zvinokonzeresa yakawandisa steric chipingamupinyi.Saizvozvo, kubatana pakati pemadomasi maviri epuroteni kazhinji kunoda glycine kuti ipe conformational flexibility.Zvisinei, kana glycine inoshanduka zvakakwana, kugadzikana kwayo hakuna kukwana.
Glycine ndeimwe yevaparadzi panguva yekuumbwa kwe-α-helix.Chikonzero ndechekuti maketani eparutivi idiki zvakanyanya kuti agadzikane conformation zvachose.Mukuwedzera, glycine inowanzoshandiswa kugadzirira buffer mhinduro.Avo venyu vanoita electrophoresis vanowanzoyeuka izvozvo.
Zita reChirungu rekuti alanine rinobva kuGerman acetaldehyde, uye zita rechiChinese riri nyore kunzwisisa nekuti alanine ine makabhoni matatu uye kemikari yayo inonzi alanine.Iri izita riri nyore, sezvakaita hunhu hweamino acid.The side chain of alanine ine chete methyl boka uye yakakura zvishoma pane iyo yeglycine.Pandakadhirowa maumbirwo emamwe 18 amino acids, ndakawedzera mapoka kune alanine.Mumapuroteni, alanine yakafanana nechidhinha, chinhu chakajairika chekuvaka chisingapesani nemunhu.
Iketani yeparutivi yealanine ine zvipingamupinyi zvishoma uye iri mu α-helix, inova conformation.Iyo zvakare yakagadzikana zvakanyanya kana β-yakapetwa.Muprotein engineering, kana iwe uchida kushandura amino acid pasina chakanangana neprotein, unogona kazhinji kuishandura kuita alanine, izvo zvisiri nyore kuparadza kuwirirana kweprotein.
Nguva yekutumira: May-29-2023