Penicillin ndiyo yaive mushonga wekutanga pasi rose kushandiswa mumakiriniki.Pashure pemakore ebudiriro, mishonga inorwisa mabhakitiriya yakawanda yamuka, asi chinetso chokusabatwa nemishonga chinokonzerwa nokushandiswa kwakapararira kwemishonga inorwisa mabhakitiriya chazova chakakurumbira zvishoma nezvishoma.
Antimicrobial peptides inoonekwa seine yakafara tarisiro yekushandiswa nekuda kweiyo yakakwira antibacterial chiitiko, yakafara antibacterial spectrum, akasiyana, yakafara sarudzo, uye yakaderera kuramba shanduko mumhando dzakatarwa.Parizvino, akawanda antimicrobial peptides ari mukiriniki yekutsvagisa nhanho, pakati peiyo magainins (Xenopus laevis antimicrobial peptide) yakapinda Ⅲ yekiriniki kuyedzwa.
Yakanyatsotsanangurwa maitiro ekushanda
Antimicrobial peptides (amps) ndiwo mapolypeptides ane huremu hwe20000 uye ane antibacterial chiitiko.Pakati pe ~ 7000 uye inoumbwa ne20 kusvika ku60 amino acid zvisaririra.Mazhinji eaya anoshanda peptides ane hunhu hwehwaro hwakasimba, kugadzikana kwekupisa, uye yakakura-spectrum antibacterial.
Zvichienderana nechimiro chavo, antimicrobial peptides inogona kukamurwa kuita zvikamu zvina: helical, sheet, kureba, uye mhete.Mamwe antimicrobial peptides anosanganisira zvachose helix imwe chete kana pepa, asi mamwe ane chimiro chakaoma.
Iyo inonyanyozivikanwa maitiro ekuita kweantimicrobial peptides ndeyekuti vane yakananga basa kurwisa mabhakitiriya cell membranes.Muchidimbu, antimicrobial peptides inovhiringidza kugona kwebhakitiriya membrane, shandura membrane permeability, leak metabolites, uye pakupedzisira inotungamira kurufu rwebhakitiriya.Iyo yekuchaja yemhando yeantimicrobial peptides inobatsira kuvandudza kugona kwavo kupindirana nebhakitiriya cell membranes.Mazhinji antimicrobial peptides ane net positive charge uye nekudaro anonzi cationic antimicrobial peptides.Kudyidzana kwe electrostatic pakati pe cationic antimicrobial peptides uye anionic bacterial membranes inodzikamisa kusungwa kweantimicrobial peptides kune bacteria membranes.
Emerging kurapa kugona
Kugona kweantimicrobial peptides kuita kuburikidza nemaitiro akawanda uye nzira dzakasiyana kwete chete kuwedzera antimicrobial chiitiko asiwo kunoderedza propensity yekuramba.Kuita kuburikidza nematanho akawanda, mukana wekuti mabhakitiriya awane akawanda ekuchinja panguva imwe chete anogona kudzikiswa zvakanyanya, zvichipa antimicrobial peptides yakanaka kuramba.Pamusoro pezvo, nekuti akawanda antimicrobial peptides anoshanda pane bacterial cell membrane masosi, mabhakitiriya anofanirwa kugadzirisa zvachose chimiro chesero membrane kuti chishanduke, uye zvinotora nguva yakareba kuti shanduko dzakawanda dziitike.Izvo zvakajairika mukenza chemotherapy kudzikamisa bundu kuramba uye kuramba zvinodhaka nekushandisa nzira dzakawanda uye maajenti akasiyana.
Tarisiro yekiriniki yakanaka
Gadzira mishonga mitsva yeantimicrobial kudzivirira dambudziko rinotevera reantimicrobial.Nhamba huru yeantimicrobial peptides iri kuedzwa nekiriniki uye inoratidza kugona kwekiriniki.Basa rakawanda richiri kufanira kuitwa paantimicrobial peptides senovel antimicrobial agents.Mazhinji antimicrobial peptides mumakiriniki ekuyedzwa haakwanise kuunzwa kumusika nekuda kwekutadza dhizaini yekuyedza kana kushomeka kwechokwadi.Naizvozvo, tsvakiridzo yakawanda pamusoro pekudyidzana kwepeptide-based antimicrobials neyakaomarara nharaunda yevanhu ichave yakakosha kuongorora kugona kwechokwadi kwemishonga iyi.
Chokwadi, makomisheni mazhinji mumakiriniki ekuyedzwa akagadziridzwa kemikari kuti avandudze maitiro avo ekurapa.Mukuita izvi, kushandiswa nesimba kwemaraibhurari epamusoro edhijitari uye kugadzirwa kwemodelling software kuchawedzera kukwenenzvera nekuvandudzwa kwemishonga iyi.
Kunyangwe dhizaini uye kuvandudzwa kweantimicrobial peptides riri basa rine musoro, isu tinofanirwa kuyedza kudzikamisa kupikisa kweaantimicrobial agents.Kuenderera mberi kwekuvandudzwa kweakasiyana maantimicrobial agents uye nzira dzeantimicrobial zvichabatsira kudzikisira kukanganiswa kwemishonga inorwisa mabhakitiriya.Uye zvakare, kana mumiriri mutsva weantibacterial akaiswa pamusika, kutarisisa kwakadzama uye manejimendi kunodiwa kudzikamisa kushandiswa kusingaite kweanorwisa mabhakitiriya zvakanyanya sezvinobvira.
Nguva yekutumira: Jul-04-2023